Innovations in the development of water-soluble polymer systems for drug delivery
Keywords:
water-soluble polymers, sodium alginate, hydrogels, rheological properties, drug delivery, dentistry, innovations, pharmaceutical ingredientsSynopsis
This study focuses on developing and investigating innovative water-soluble polymer systems based on sodium alginate for drug delivery, specifically for controlled lidocaine release. A novel hydrogel was formulated with a unique composition, including sodium alginate, azithromycin, lidocaine, and levomenthol, among other auxiliary components. These hydrogels exhibit a significant capacity for water absorption, directly proportional to the sodium alginate concentration. Enhanced moisture retention was observed, attributed to the proposed hydrogel composition and its excipients. The hydrogels demonstrate non-Newtonian, pseudoplastic behavior, with viscosity dependent on both sodium alginate concentration and temperature; an increase in temperature notably reduces hydrogel viscosity. Furthermore, the research confirms the feasibility of controlled and prolonged drug release, particularly for lidocaine, with approximately 60 % of lidocaine released within 60 minutes and over 80 % within 90 minutes. Ultimately, optimizing sodium alginate concentration and controlling temperature allow for the targeted regulation of key hydrogel properties, including water absorption, viscosity, and release kinetics. These findings highlight the broad potential for applying sodium alginate-based hydrogels in the pharmaceutical industry to create advanced controlled-release systems, especially for lidocaine delivery.
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Lai, W.-F., Rogach, A. L. (2017). Hydrogel-Based Materials for Delivery of Herbal Medicines. ACS Applied Materials & Interfaces, 9 (13), 11309–11320. https://doi.org/10.1021/acsami.6b16120
Xue, W., Zhang, M., Zhao, F., Wang, F., Gao, J., Wang, L. (2019). Long-term durability antibacterial microcapsules with plant-derived Chinese nutgall and their applications in wound dressing. E-Polymers, 19 (1), 268–276. https://doi.org/10.1515/epoly-2019-0027
Lin, N., Gèze, A., Wouessidjewe, D., Huang, J., Dufresne, A. (2016). Biocompatible Double-Membrane Hydrogels from Cationic Cellulose Nanocrystals and Anionic Alginate as Complexing Drugs Codelivery. ACS Applied Materials & Interfaces, 8 (11), 6880–6889. https://doi.org/10.1021/acsami.6b00555
Hariyadi, D. M., Islam, N. (2020). Current Status of Alginate in Drug Delivery. Advances in Pharmacological and Pharmaceutical Sciences, 2020, 1–16. https://doi.org/10.1155/2020/8886095
Kadajji, V. G., Betageri, G. V. (2011). Water Soluble Polymers for Pharmaceutical Applications. Polymers, 3 (4), 1972–2009. https://doi.org/10.3390/polym3041972
Al-Roujayee, A. S., Hilaj, E., Deepak, A., Jyothi, S. R., Hamid, J. A., Ariffin, I. A. et al. (2024). Alginate-based systems: advancements in drug delivery and wound healing. International Journal of Polymeric Materials and Polymeric Biomaterials, 74 (9), 846–874. https://doi.org/10.1080/00914037.2024.2375343
Sharma, A., Gupta, M. N. (2002). Three phase partitioning of carbohydrate polymers: separation and purification of alginates. Carbohydrate Polymers, 48 (4), 391–395. https://doi.org/10.1016/s0144-8617(01)00313-7
Yang, J.-S., Xie, Y.-J., He, W. (2011). Research progress on chemical modification of alginate: A review. Carbohydrate Polymers, 84 (1), 33–39. https://doi.org/10.1016/j.carbpol.2010.11.048
Rhein-Knudsen, N., Ale, M. T., Ajalloueian, F., Meyer, A. S. (2017). Characterization of alginates from Ghanaian brown seaweeds: Sargassum spp. and Padina spp. Food Hydrocolloids, 71, 236–244. https://doi.org/10.1016/j.foodhyd.2017.05.016
Otterlei, M., Østgaard, K., Skjåk-Bræk, G., Smidsrød, O., Soon-Shiong, P., Espevik, T. (1991). Induction of Cytokine Production from Human Monocytes Stimulated with Alginate. Journal of Immunotherapy, 10 (4), 286–291. https://doi.org/10.1097/00002371-199108000-00007
Johnson, F. A., Craig, D. Q. M., Mercer, A. D. (1997). Characterization of the Block Structure and Molecular Weight of Sodium Alginates. Journal of Pharmacy and Pharmacology, 49 (7), 639–643. https://doi.org/10.1111/j.2042-7158.1997.tb06085.x
Fu, S., Thacker, A., Sperger, D. M., Boni, R. L., Buckner, I. S., Velankar, S. et al. (2011). Relevance of Rheological Properties of Sodium Alginate in Solution to Calcium Alginate Gel Properties. AAPS PharmSciTech, 12 (2), 453–460. https://doi.org/10.1208/s12249-011-9587-0
Ching, S. H., Bansal, N., Bhandari, B. (2015). Alginate gel particles–A review of production techniques and physical properties. Critical Reviews in Food Science and Nutrition, 57 (6), 1133–1152. https://doi.org/10.1080/10408398.2014.965773
Szekalska, M., Puciłowska, A., Szymańska, E., Ciosek, P., Winnicka, K. (2016). Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. International Journal of Polymer Science, 2016, 1–17. https://doi.org/10.1155/2016/7697031
Deng, Y., Yang, N., Valentine Okoro, O., Shavandi, A., Nie, L. (2022). Alginate-Based Composite and Its Biomedical Applications. Properties and Applications of Alginates. https://doi.org/10.5772/intechopen.99494
Tam, S. K., Dusseault, J., Bilodeau, S., Langlois, G., Hallé, J., Yahia, L. (2011). Factors influencing alginate gel biocompatibility. Journal of Biomedical Materials Research Part A, 98A (1), 40–52. https://doi.org/10.1002/jbm.a.33047
de Vos, P., Faas, M. M., Strand, B., Calafiore, R. (2006). Alginate-based microcapsules for immunoisolation of pancreatic islets. Biomaterials, 27 (32), 5603–5617. https://doi.org/10.1016/j.biomaterials.2006.07.010
Kesharwani, P., Sharma, S., Chaudhary, V., Goyal, R., Gautam, R. K. (2024). Biomedical Applications of Alginates. Biopolymers for Biomedical Applications, 53–86. https://doi.org/10.1002/9781119865452.ch3
Ahmad Raus, R., Wan Nawawi, W. M. F., Nasaruddin, R. R. (2021). Alginate and alginate composites for biomedical applications. Asian Journal of Pharmaceutical Sciences, 16 (3), 280–306. https://doi.org/10.1016/j.ajps.2020.10.001
Venkatesan, J., Bhatnagar, I., Manivasagan, P., Kang, K.-H., Kim, S.-K. (2015). Alginate composites for bone tissue engineering: A review. International Journal of Biological Macromolecules, 72, 269–281. https://doi.org/10.1016/j.ijbiomac.2014.07.008
Bidarra, S. J., Barrias, C. C., Granja, P. L. (2014). Injectable alginate hydrogels for cell delivery in tissue engineering. Acta Biomaterialia, 10 (4), 1646–1662. https://doi.org/10.1016/j.actbio.2013.12.006
Grothe, T., Grimmelsmann, N., Homburg, S. V., Ehrmann, A. (2017). Possible applications of nano-spun fabrics and materials. Materials Today: Proceedings, 4, S154–S159. https://doi.org/10.1016/j.matpr.2017.09.180
Namviriyachote, N., Lipipun, V., Akkhawattanangkul, Y., Charoonrut, P., Ritthidej, G. C. (2019). Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound. Asian Journal of Pharmaceutical Sciences, 14 (1), 63–77. https://doi.org/10.1016/j.ajps.2018.09.001
Holak, P., Adamiak, Z., Babinska, I., Jalynski, M., Jastrzebski, P., Grabarczyk, L. et al. (2019). The Influence of Haemostatic Dressing Prototypes for the Emergency Services on the Histopathological Parameters of Porcine Muscle. In Vivo, 33 (3), 723–729. https://doi.org/10.21873/invivo.11531
Kurczewska, J., Pecyna, P., Ratajczak, M., Gajęcka, M., Schroeder, G. (2017). Halloysite nanotubes as carriers of vancomycin in alginate-based wound dressing. Saudi Pharmaceutical Journal, 25 (6), 911–920. https://doi.org/10.1016/j.jsps.2017.02.007
Sharifi, F., Sooriyarachchi, A. C., Altural, H., Montazami, R., Rylander, M. N., Hashemi, N. (2016). Fiber Based Approaches as Medicine Delivery Systems. ACS Biomaterials Science & Engineering, 2 (9), 1411–1431. https://doi.org/10.1021/acsbiomaterials.6b00281
Lai, W.-F., Rogach, A. L. (2017). Hydrogel-Based Materials for Delivery of Herbal Medicines. ACS Applied Materials & Interfaces, 9 (13), 11309–11320. https://doi.org/10.1021/acsami.6b16120
Xue, W., Zhang, M., Zhao, F., Wang, F., Gao, J., Wang, L. (2019). Long-term durability antibacterial microcapsules with plant-derived Chinese nutgall and their applications in wound dressing. E-Polymers, 19 (1), 268–276. https://doi.org/10.1515/epoly-2019-0027
Lin, N., Gèze, A., Wouessidjewe, D., Huang, J., Dufresne, A. (2016). Biocompatible Double-Membrane Hydrogels from Cationic Cellulose Nanocrystals and Anionic Alginate as Complexing Drugs Codelivery. ACS Applied Materials & Interfaces, 8 (11), 6880–6889. https://doi.org/10.1021/acsami.6b00555
Text Identifier of this Chapter
Chapter 2
Published
April 29, 2025
Series
Copyright (c) 2026 Olena Ishchenko, Olha Sumska , Volodymyr Bessarabov, Galyna Kuzmina, Liudmyla Vognivenko, Natalia Pelykh
How to Cite
Ishchenko, O., Sumska, O., Bessarabov, V., Kuzmina, G., Vognivenko, L., & Pelykh, N. (2025). Innovations in the development of water-soluble polymer systems for drug delivery. In Y. Pushkarova, G. Zaitseva, O. Ishchenko, O. Sumska, V. Bessarabov, G. Kuzmina, L. Vognivenko, N. Pelykh, N. Minska, A. Huz, V. Kradozhon, R. Melezhyk, M. Murin, V. Rotar, & N. Tregub, In press. Chemical engineering: innovations in materials and processes. Scientific Route OÜ®. https://monograph.route.ee/rout/catalog/book/Chemical_engineering_innovations_in_materials_and_processes/chapter/165
